Person · familial hypercholesterolemia crossover trial · study authors
“The WFPB induced a clinically significant reduction in LDL-C relative to the SAD”
study authors, Nature Communications
A randomized, fully controlled crossover feeding trial in 50 genetically confirmed patients, with results the authors call clinically significant enough to reestablish diet as a frontline therapy.
In the brief: Whole-food plant-based diet cuts LDL cholesterol 17.9% in genetic high-cholesterol trial → Primary Sources →
“The WFPB induced a clinically significant reduction in LDL-C relative to the SAD (−17.9%, 95% CI: −21.7%, −14.3%; P < 0.0001)”
Nature Communications, familial hypercholesterolemia crossover trial
This is a peer-reviewed, fully controlled feeding trial with a genetically confirmed patient population, though the sample is small (50 adults) and industry-funded dairy-consulting ties exist for one author unrelated to the diet arm.
In the brief: Whole-food plant-based diet cuts LDL 17.9% in genetic high-cholesterol trial → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →
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